What is Nifurfurtel
Nifurfurtel is an antibacterial drug widely used in gynecology, urology and gastroenterology. In recent years, it has become a hot topic in the medical field due to its unique pharmacological effects and clinical effects. This article will combine the hot content of the entire Internet in the past 10 days to provide you with a comprehensive analysis of Nifurtel from the aspects of definition, pharmacological effects, indications, side effects and precautions for use.
1. Definition and basic information of Nifurotel
Nifuratel is a nitrofuran derivative with broad-spectrum antibacterial, antifungal and antitrichomoniasis effects. Its chemical structure is similar to nitrofurantoin, but its efficacy and safety are optimized.
| Project | content |
|---|---|
| chemical name | 5-(Methylthiomethyl)-3-[(5-nitrofuran-2-yl)methyleneamino]oxazolidin-2-one |
| Molecular formula | C10H11N3O5S |
| molecular weight | 285.28 g/mol |
| Traits | Yellow crystalline powder |
2. Pharmacological effects and mechanisms
Nifurfurtel exerts antibacterial effects by interfering with the DNA synthesis and energy metabolism of microorganisms. Its mechanism of action mainly includes:
| microbial type | Effect |
|---|---|
| Bacteria | It has inhibitory effect on both Gram-positive bacteria and Gram-negative bacteria. |
| Fungi | Effective against common pathogenic fungi such as Candida albicans |
| Trichomonas | It has a significant killing effect on Trichomonas vaginalis |
3. Main indications
According to clinical research and medication guidelines, nifuratel is mainly used for the treatment of the following diseases:
| disease type | specific disease |
|---|---|
| Gynecological infection | Bacterial vaginosis, trichomonas vaginitis, vulvovaginal candidiasis |
| urinary tract infection | urethritis, cystitis |
| Digestive system infection | Amoebic dysentery, giardiasis |
4. Usage and dosage
The usage and dosage of Nifurtel should be adjusted according to the specific dosage form and indications:
| Dosage form | Usage | Dosage |
|---|---|---|
| tablet | Oral | Adults: 200mg each time, 3 times a day, for 7 days |
| vaginal suppository | Vaginal administration | 1 capsule (250mg) every night for 6-10 days |
| Ointment | External use | Apply to the affected area 1-2 times a day |
5. Adverse reactions and precautions
The overall safety of Nifurfurtel is good, but the following matters still need to be noted:
| adverse reactions | incidence | Treatment measures |
|---|---|---|
| gastrointestinal reactions | about 5% | Taking it after meals can reduce symptoms |
| allergic reaction | rare | Stop medication immediately and seek medical advice |
| local irritation | about 3% | Reduce medication frequency or change dosage forms |
6. Medication for Special Populations
| crowd | Medication recommendations |
|---|---|
| pregnant woman | Use with caution, doctor needs to evaluate the risk-benefit ratio |
| lactating women | It is recommended to suspend breastfeeding or choose other drugs |
| children | Insufficient safety data for children under 12 years of age |
| People with liver and kidney dysfunction | Dosage adjustment is required and close monitoring is required |
7. Drug interactions
Nifurfurtel may interact with the following drugs:
| Combination drugs | interaction |
|---|---|
| Antacids | May decrease nifuratel absorption |
| alcohol | Increased risk of disulfiram-like reactions |
| warfarin | May enhance anticoagulant effect |
8. Clinical Research and Latest Progress
According to recent clinical research data:
| Research content | result |
|---|---|
| Bacterial vaginosis treatment | The cure rate is 85-92% |
| Trichomonas vaginitis treatment | More than 90% effective |
| Candida infection treatment | Effectiveness is about 80% |
9. Summary
Nifurfurtel, as a broad-spectrum anti-infective drug, plays an important role in the treatment of gynecological, urological and gastroenterological infections. Its advantages include broad antibacterial spectrum, low drug resistance, and low local irritation. However, you still need to strictly follow medical instructions when using it, and pay attention to drug interactions and medication safety for special groups.
With the deepening of medical research, the application scope and clinical value of nifuratel are still expanding. More research results on its new indications and combination regimens may be released in the future.
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